Two sample MR report
CD52_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 17 | 0.0421569 | 0.0395087 | 0.3028316 |
| Weighted median | 17 | 0.0450720 | 0.0090370 | 0.0000006 |
| Inverse variance weighted | 17 | 0.0312592 | 0.0078925 | 0.0000748 |
| Simple mode | 17 | 0.0504170 | 0.0140588 | 0.0024705 |
| Weighted mode | 17 | 0.0493491 | 0.0123285 | 0.0010259 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 27.75639 | 15 | 0.0231447 |
| Inverse variance weighted | 27.90340 | 16 | 0.0324699 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0064651 | 0.0229368 | 0.7818996 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0007001 | 0 | TRUE | 0.0121736 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
